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Near-Infrared Photothermal Release of siRNA from the Surface of Colloidal Gold–Silver–Gold Core–Shell–Shell Nanoparticles Studied with Second-Harmonic Generation
journal contribution
posted on 2018-08-06, 00:00 authored by Raju R. Kumal, Mohammad Abu-Laban, Prakash Hamal, Blake Kruger, Holden T. Smith, Daniel J. Hayes, Louis H. HaberPhotothermal release
of oligonucleotides from the surface of plasmonic
nanoparticles represents a promising platform for spatiotemporal controlled
drug delivery. Here we demonstrate the use of novel gold–silver–gold
core–shell–shell (CSS) nanoparticles to study the photothermal
cleaving and release of micro-RNA (miRNA) mimics or small interfering
RNA (siRNA) under near-infrared (NIR) irradiation. The furan–maleimide-based
Diels–Alder adduct cleaves thermally above 60 °C and is
used to bind siRNA to the colloidal nanoparticle surface in water.
We investigate the photothermal cleaving kinetics of siRNA under different
NIR laser powers using surface-sensitive time-dependent second-harmonic
generation (SHG) spectroscopy. The photothermal release of siRNA
from the surface of CSS nanoparticles is significantly higher than
that from the surface of gold nanoparticles (GNPs) under similar experimental
conditions. These results demonstrate that plasmonic CSS nanoparticles
with photothermal cleaving linkers have important potential applications
for nanoparticle-based NIR-mediated drug-delivery systems.
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CSS nanoparticlesphotothermal cleaving kineticsNIR laser powersphotothermal cleaving linkersSHGSecond-Harmonic Generation Photothermal releaseplasmonic CSS nanoparticlesplasmonic nanoparticlesNear-Infrared Photothermal Releasephotothermal cleavingsurface-sensitive time-dependent second-harmonic generationGNPnanoparticle-based NIR-mediatedgold nanoparticlesbind siRNAphotothermal releasedrug deliverynanoparticle surface
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