ac6b03039_si_001.pdf (1.06 MB)
Near-Infrared Photoacoustic Imaging Probe Responsive to Calcium
journal contribution
posted on 2016-10-25, 00:00 authored by Anurag Mishra, Yuanyuan Jiang, Sheryl Roberts, Vasilis Ntziachristos, Gil G. WestmeyerPhotoacoustic
imaging (PAI) is an attractive imaging modality that can volumetrically
map the distribution of photoabsorbing molecules with deeper tissue
penetration than multiphoton microscopy. To enable dynamic sensing
of divalent cations via PAI, we have engineered a new reversible near-infrared
probe that is more sensitive to calcium as compared to other biologically
relevant cations. The metallochromic compound showed a strong reduction
of its peak absorbance at 765 nm upon addition of calcium ions that
was translated into robust signal changes in photoacoustic images.
Therefore, the heptamethine cyanine dye will be an attractive scaffold
to create a series of metallochromic sensors for molecular PAI.
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Near-Infrared Photoacoustic Imaging Probe Responsivecalcium ionsPAIheptamethine cyanine dyedivalent cationsmetallochromic compoundCalcium Photoacoustic imagingsignal changespeak absorbancemultiphoton microscopy765 nmphotoabsorbing moleculesimaging modalitynear-infrared probephotoacoustic imagesmetallochromic sensorstissue penetration
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