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Near-Infrared Light Responsive Nanoreactor for Simultaneous Tumor Photothermal Therapy and Carbon Monoxide-Mediated Anti-Inflammation
journal contribution
posted on 2020-03-23, 04:29 authored by Shi-Bo Wang, Cheng Zhang, Jing-Jie Ye, Mei-Zhen Zou, Chuan-Jun Liu, Xian-Zheng ZhangPhotothermal therapy
(PTT) is an effective treatment modality with
high selectivity for tumor suppression. However, the inflammatory
responses caused by PTT may lead to adverse reactions including tumor
recurrence and therapeutic resistance, which are regarded as major
problems for PTT. Here, a near-infrared (NIR) light-responsive nanoreactor
(P@DW/BC) is fabricated to simultaneously realize tumor PTT and carbon
monoxide (CO)-mediated anti-inflammatory therapy. Defective tungsten
oxide (WO3) nanosheets (DW NSs) are decorated with bicarbonate
(BC) via ferric ion-mediated coordination and then modified with polyethylene
glycol (PEG) on the surface to fabricate PEG@DW/BC or P@DW/BC nanosheets.
Upon 808 nm NIR laser irradiation, the DW content in P@DW/BC can serve
as not only a photothermal agent to realize photothermal conversion
but also a photocatalyst to convert carbon dioxide (CO2) to CO. In particular, the generated heat can also trigger the decomposition
of BC to produce CO2 near the NSs, thus enhancing the photocatalytic
CO generation. Benefiting from the efficient hyperthermia and CO generation
under single NIR laser irradiation, P@DW/BC can realize effective
thermal ablation of tumor and simultaneous inhibition of PTT-induced
inflammation.
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BCWOSimultaneous Tumor Photothermal TherapyPTTCarbon Monoxide-Mediated Anti-Inflammation Photothermal therapyphotocatalytic CO generationCO 2tumor808 nm NIR laser irradiationPEGNIR laser irradiationNSferric ion-mediated coordinationDWDefective tungsten oxideNear-Infrared Light Responsive Nanoreactor
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