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Near-Infrared Excited Orthogonal Emissive Upconversion Nanoparticles for Imaging-Guided On-Demand Therapy
journal contribution
posted on 2019-08-25, 20:29 authored by Ming Tang, Xiaohui Zhu, Yuehong Zhang, Zeping Zhang, Zhiming Zhang, Qingsong Mei, Jing Zhang, Minghong Wu, Jinliang Liu, Yong ZhangPhotodynamic therapy
(PDT) has been considered as a promising and
noninvasive strategy for clinical cancer treatment. Nonetheless, building
a smart “off–on” theranostic PDT platform to
spatiotemporally control the generation of reactive oxygen species
in the PDT treatment still remains challenging. Here, we have rationally
developed photoswitching upconversion nanoparticles (UCNPs) with orthogonal
emissive properties in response to two distinct near-infrared (NIR)
emissions at 808 and 980 nm, i.e., red emission with
980 nm excitation and green emission with 808 nm excitation. Unlike
traditional photoswitching UCNPs, these specially designed core–shell–shell
structured UCNPs do not require complicated multilayer doping as their
red and green upconversion luminescence both originate from the same
activator Er3+ ions in the core structure. As a proof of
concept, we have demonstrated the capability of these orthogonal emissive
UCNPs for imaging-guided PDT in a real-time manner, where the red
emission excited by 980 nm light is used to trigger PDT and the green
emission with 808 nm excitation is to diagnose and monitor the therapeutic
treatment. Our study suggests that such specially designed UCNPs with
orthogonal emissions hold great promise for NIR light-targeted and
imaging-guided therapy under precisely spatiotemporal control.
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orthogonal emissions980 nmspatiotemporally controlspatiotemporal controlnoninvasive strategyphotoswitching UCNPsreactive oxygen speciesupconversion luminescence980 nm excitationImaging-Guided On-Demand Therapy Photodynamic therapy980 nm lightimaging-guided therapyNIR light-targetedimaging-guided PDTNear-Infrared Excited Orthogonal Emissive Upconversion NanoparticlesPDT treatmentorthogonal emissive propertiescore structurephotoswitching upconversion nanoparticlescancer treatmentorthogonal emissive UCNPs808 nm excitation
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