posted on 2019-06-10, 00:00authored byZhaojie Li, Hao Zhang, Shouyun Yu
A new class of C–N axial chirality
based on N-indole sulfonamides has been disclosed.
This new axially chiral N-indole sulfonamides were
constructed by NaClO-promoted
couplings of 3-substituted indoles with chiral amino acid-based sulfonamides.
A series of structurally diverse N-indole sulfonamide-based
atropisomers were prepared using this established method. The stability
of these structurally interesting atropisomers highly relied on the
C3-substituents of indoles and side chains of amino acid derivatives.