ol7b00908_si_001.pdf (1.09 MB)
N‑Trifluoromethylation of Nitrosoarenes with Sodium Triflinate
journal contribution
posted on 2017-04-12, 18:48 authored by Angela van der Werf, Matic Hribersek, Nicklas SelanderA highly efficient
N-trifluoromethylation of nitrosoarenes is reported.
The inexpensive and convenient Langlois reagent (sodium triflinate)
is employed as a CF3-radical source in combination with
a copper catalyst and an oxidant. N-Trifluoromethylated hydroxylamines
are obtained in high yields within 1 h at room temperature. The addition
of hydroquinone was found to be instrumental to prevent the formation
of side products. The method is high-yielding, is scalable, and displays
a high functional group tolerance.