jo302751p_si_001.pdf (2.24 MB)
NIS-Mediated Electrophilic Cyclization of 3‑Silyloxy-1,n‑enynes
journal contribution
posted on 2013-03-15, 00:00 authored by Florian Huber, Stefan F. KirschThe electrophilic cyclization of 3-silyloxy-1,5-enynes
and 3-silyloxy-1,6-enynes
was investigated. In the presence of N-iodosuccinimide
(NIS), the title compounds are transformed under metal-free conditions
into five-membered carbocycles with all-carbon stereogenic centers
following a sequence of iodonium activation of the triple bond, carbocyclization,
and pinacol-type 1,2-shift.