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NIR Light-Degradable Antimony Nanoparticle-Based Drug-Delivery Nanosystem for Synergistic Chemo–Photothermal Therapy in Vitro
journal contribution
posted on 2019-12-14, 03:29 authored by Solomon
Tiruneh Dibaba, Riccarda Caputo, Wensong Xi, Jin Z. Zhang, Ruoyan Wei, Qiang Zhang, Jianhua Zhang, Wei Ren, Lining SunA novel drug-delivery nanosystem based on near-infrared
(NIR) light-degradable
antimony nanoparticles (AMNP) have been developed for synergistic
chemo–phototherapy in vitro. The monodispersed AMNP were synthesized
by using a simple and cost-effective method. Positively charged doxorubicin
hydrochloride (DOX) was loaded onto the negatively charged surface
of AMNP via electrostatic interaction and finally modified by polyacrylic
acid (PAA) to enhance biocompatibility. Under NIR (808 nm) laser irradiation
of the AMNP–DOX–PAA nanosystem, not only was high photothermal
conversion efficiency of AMNP achieved but also pH-dependent DOX release
was enhanced due to laser-induced hyperthermia. As a consequence,
almost all of the HeLa cells (around 97%) were killed because of the
combined effects of chemotherapy and photothermal therapy. More interestingly,
AMNP showed very fast (about 10 min) laser-induced degradation that
may help to minimize long-term toxicity after therapy by using same-wavelength
NIR laser irradiation (808 nm). Computational total energy calculations
and molecular dynamics simulations based on density functional theory
(DFT) suggest that the NIR laser irradiation induces a photothermally
activated reaction on the surface of AMNP in water, which can lead
to surface degradation via the formation of Sb–H bonds first
and then Sb–OH bonds upon further increase of temperature.
This work demonstrates a simple platform that has potential applications
for synergistic and highly effective chemo–photothermal therapy
based on photodegradable nanoparticles.
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Keywords
PAAphotothermal therapyphotothermal conversion efficiencymonodispersed AMNPlaser irradiation10 minsurface degradationlaser-induced hyperthermiaHeLa cellspolyacrylic acidNIR laser irradiationDFTpH-dependent DOX releaselight-degradable antimony nanoparticlesNIR Light-Degradable Antimony Nanoparticle-Based Drug-Delivery Nanosystemlaser-induced degradationphotodegradable nanoparticlesdoxorubicin hydrochlorideenergy calculationsdynamics simulations
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