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Mussel-Inspired Multivalent Linear Polyglycerol Coatings Outperform Monovalent Polyethylene Glycol Coatings in Antifouling Surface Properties
journal contribution
posted on 2019-11-19, 16:04 authored by Michaël
W. Kulka, Ievgen S. Donskyi, Nina Wurzler, Dirk Salz, Özlem Özcan, Wolfgang E. S. Unger, Rainer HaagBiofouling constitutes a major challenge in the application
of
biosensors and biomedical implants, as well as for (food) packaging
and marine equipment. In this work, an antifouling surface coating
based on the combination of mussel-inspired dendritic polyglycerol
(MI-dPG) and an amine-functionalized block copolymer of linear polyglycerol
(lPG–b–OA11, OA = oligo-amine) was developed.
The coating was compared to a MI-dPG surface which was postfunctionalized
with commercially available amine-terminated polyethylene glycol (HO–PEG–NH2) of similar molecular weight. In the current work, these
coatings were compared in their chemical stability, protein fouling
characteristics, and cell fouling characteristics. The lPG–b–OA11-functionalized coating showed high chemical stability in
both phosphate buffered saline (PBS) and sodium dodecyl sulfate (SDS)
solutions and reduced the adhesion of fibrinogen from human plasma
with 99% and the adhesion of human serum albumin with 96%, in comparison
to the bare titanium dioxide substrate. Furthermore, the proliferation
of human umbilical vein endothelial cells (HUVECs) was reduced with
85% when the lPG–b–OA11 system was compared
to bare titanium dioxide. Additionally, a reduction of 94% was observed
when the lPG–b–OA11 system was compared to
tissue culture polystyrene.
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titanium dioxide substrateantifouling surface coatingchemical stabilityamine-functionalized block copolymerprotein fouling characteristicsOAmussel-inspired dendritic polyglycerolPBStissue culture polystyreneadhesionMussel-Inspired Multivalent Linear Polyglycerol Coatings Outperform Monovalent Polyethylene Glycol Coatingscell fouling characteristicssodium dodecyl sulfateAntifouling Surface Properties BiofoulinglPGHOHUVECSDSMI-dPGamine-terminated polyethylene glycol
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