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Multifunctional Surface with Enhanced Angiogenesis for Improving Long-Term Osteogenic Fixation of Poly(ether ether ketone) Implants
Version 2 2020-03-23, 17:33
Version 1 2020-03-20, 13:09
journal contribution
posted on 2020-03-23, 17:33 authored by Taosheng Dong, Chunyan Duan, Song Wang, Xiangyu Gao, Qizhang Yang, Weizhong Yang, Yi DengPoly(ether
ether ketone) (PEEK) is a biocompatible polymer, but the lack of angiogenesis
makes the long-term osteogenic fixation of PEEK implants challenging,
which has hampered their wider application in orthopedics. Herein,
we develop a multifunctional micro-/nanostructured surface presenting
hydroxyapatite (HA) nanoflowers and nickel hydroxide (Ni(OH)2) nanoparticles on PEEK implants (sPEEK-Ni-HA) to tackle the problem.
The results show that the reasonable release of Ni2+ from
sPEEK-Ni-HA significantly facilitates the migration, tube formation,
and angiogenic gene expression of human umbilical vein endothelial
cells (HUVECs). In addition to angiogenesis, the sPEEK-Ni-HA displays
enhanced cytocompatibility and osteogenicity in terms of cell proliferation,
spreading, alkaline phosphatase activity, matrix mineralization, and
osteogenesis-related gene secretion, exceeding pure and other multifunctional
sPEEK samples. Importantly, in vivo evaluations employing
a rabbit femoral condyle implantation model confirm that such dual
decoration of Ni elements and HA nanoflowers boosts bone remodeling/osseointegration,
which dramatically promotes the in vivo osteogenic
fixation of implants. Therefore, this work not only sheds light on
the significance of angiogenesis on the osteogenic fixation of an
implant but also presents a facile strategy to empower bioinert PEEK
with a well-orchestrated feature of angiogenesis and osteogenesis.