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Multifunctional Biomaterial Coating Based on Bio-Inspired Polyphosphate and Lysozyme Supramolecular Nanofilm
journal contribution
posted on 2018-02-12, 00:00 authored by Xinyuan Xu, Dongyue Zhang, Shangwei Gao, Toshikazu Shiba, Quan Yuan, Kai Cheng, Hong Tan, Jianshu LiCurrent implant materials have widespread
clinical applications
together with some disadvantages, the majority of which are the ease
with which infections are induced and difficulty in exhibiting biocompatibility.
For the efficient improvement of their properties, the development
of interface multifunctional modification in a simple, universal,
and environmently benign approach becomes a critical challenge and
has acquired the attention of numerous scientists. In this study,
a lysozyme-polyphosphate composite coating was fabricated for titanium(Ti)-based
biomaterial to obtain a multifunctional surface. This coating was
easily formed by sequentially soaking the substrate in reduced-lysozyme
and polyphosphate solution. Such a composite coating has shown predominant
antibacterial activity against Gram-negative bacteria (E.
coli) and improved cell adhesion, proliferation, and differentiation,
which are much better than those of the pure substrate. This facile
modification endows the biomaterial with anti-infective and potential
bone-regenerative performance for clinical applications of biomaterial
implants.
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Keywords
cell adhesionGram-negative bacteriapolyphosphate solutioncoatingbiomaterial implantsMultifunctional Biomaterial CoatingLysozyme Supramolecular Nanofilmapplicationimplant materialsBio-Inspired Polyphosphatebone-regenerative performanceinterface multifunctional modificationmultifunctional surfacesubstrate
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