om010755u_si_001.pdf (1.24 MB)
Monocyclopentadienyltitanium Aryloxide Complexes: Preparation, Characterization, and Application in Cyclization Reactions
journal contribution
posted on 2002-01-24, 00:00 authored by Shana J. Sturla, Stephen L. BuchwaldA variety of monocyclopentadienyltitanium aryloxide complexes were prepared, characterized by X-ray crystallography, and used to catalyze or mediate cyclization reactions.
Structural characterization allowed for the comparison of steric parameters of various 2,6-disubstituted aryloxide ligands. Transformations of dienes and enynesincluding the
catalysis of a 1,6-diene cycloisomerization and the intramolecular Pauson−Khand reactionwere investigated. A titanium metallacycle was prepared from a sterically hindered enyne
containing a trisubstituted olefin. The Pauson−Khand reaction of trimethylsilyl-substituted
enynes was promoted to generate α-silylcyclopentenones.