np060087n_si_002.pdf (1.33 MB)
Mono-, Bi-, and Triphenanthrenes from the Tubers of Cremastra appendiculata
journal contribution
posted on 2006-06-23, 00:00 authored by Zhen Xue, Shuai Li, Sujuan Wang, Yinhong Wang, Yongchun Yang, Jiangong Shi, Lan HeSix newphenanthrene derivatives, including three monophenanthrenes (1−3), two biphenanthrenes (4 and 5), and a
triphenanthrene (6), have been isolated from an ethanolic extract of the tubers of Cremastra appendiculata. Using
spectroscopic methods, the structures of compounds 1−6 were determined as 1-hydroxy-4,7-dimethoxy-1-(2-oxopropyl)-1H-phenanthren-2-one (1), 1,7-dihydroxy-4-methoxy-1-(2-oxopropyl)-1H-phenanthren-2-one (2), 2-hydroxy-4,7-dimethoxyphenanthrene (3), 2,7,2‘-trihydroxy-4,4‘,7‘-trimethoxy-1,1‘-biphenanthrene (4), 2,2‘-dihydroxy-4,7,4‘,7‘-tetramethoxy-1,1‘-biphenanthrene (5), and 2,7,2‘,7‘,2‘ ‘-pentahydroxy-4,4‘,4‘ ‘,7‘ ‘-tetramethoxy-1,8,1‘,1‘ ‘-triphenanthrene
(6), respectively. Compounds 1−6 and two known compounds, cirrhopetalanthin (7) and flavanthrinin (8), obtained
previously from this plant, were evaluated against six human cancer cells and a normal cell line.