ac0c00526_si_001.pdf (1.96 MB)
Monitoring Neuroinflammation with an HOCl-Activatable and Blood–Brain Barrier Permeable Upconversion Nanoprobe
journal contribution
posted on 2020-03-27, 21:30 authored by Meng Zhang, Miaomiao Zuo, Caixia Wang, Zhen Li, Qingyuan Cheng, Ju Huang, Zijun Wang, Zhihong LiuA reliable tool for
real-time tracking the neuroinflammatory progress
is highly desired for interpretation and treatment of neurological
disorders. Herein, a blood–brain barrier (BBB) permeable and
HOCl-activatable upconversion (UC) nanoprobe with NIR emission was
designed for visual study on neuroinflammation (NI) in vivo. This UC probe consists of three parts: upconversion nanoparticles
(UCNPs) as signal reporter, the Cy-HOCl dye acting as
energy acceptor of UCNPs as well as the recognition unit of HOCl,
and amphiphilic polymers endowing the probe with biocompatibility
and BBB permeability. Upon intravenous injection into mice, the probe
crossed the BBB via low-density lipoprotein receptor related protein
(LRP) mediated transcytosis and was then lightened up by overproduced
HOCl in an NI process. This probe was able to differentiate inflammation
and the normal state of the brain in LPS-induced NI and monitor the
progress of NI occurring in mice with cerebral stroke, providing a
practical tool for noninvasive and visual assessment of NI.
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UC probeamphiphilic polymers endowingupconversion nanoparticlesrecognition unitLRPoverproduced HOClNIR emissionneuroinflammatory progresstoolsignal reporterenergy acceptorNI processLPS-induced NIBBB permeabilityMonitoring Neuroinflammationlipoprotein receptorCy-HOCl dyeHOCl-activatable upconversionUCNP
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