ac6b04000_si_001.pdf (16.15 MB)
Monitoring Isomerization of Molecules in Solution Using Ion Mobility Mass Spectrometry
journal contribution
posted on 2016-12-06, 00:00 authored by James
N. Bull, Michael S. Scholz, Neville J. A. Coughlan, Akio Kawai, Evan J. BieskeAn
ion mobility spectrometer (IMS) with an electrospray ion source
is used to investigate photo and thermal isomerization of photoactive
molecules in the electrospray syringe. A light emitting diode adjacent
to the syringe establishes a photostationary state that relaxes thermally
toward the more stable isomer once illumination ceases. The arrangement
is demonstrated by measuring Z–E thermal isomerization rates for several azoheteroarene compounds.
The IMS technique has a distinct advantage over UV–vis spectrophotometry
for measuring isomer populations in situations where there are multiple
isomers with overlapping absorption profiles. In another development,
an LED array adjacent to the silica capillary connecting the syringe
to the electrospray ion source, is used to activate photochromic molecules,
and investigate sequential photoswitching events.
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photochromic moleculesazoheteroarene compoundsMonitoring Isomerizationelectrospray ion sourceIon Mobility Mass Spectrometryabsorption profilesphotostationary stateIMS techniqueisomer populationsion mobility spectrometerLED arrayphotoactive moleculessequential photoswitching eventsUVelectrospray syringeisomerization ratessilica capillary
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