ao9b01481_si_001.pdf (2.15 MB)
Molecular Iodine-Catalyzed Selective C‑3 Benzylation of Indoles with Benzylic Alcohols: A Greener Approach toward Benzylated Indoles
journal contribution
posted on 2019-07-08, 08:13 authored by Prantika Bhattacharjee, Utpal BoraIodine-catalyzed selective C-3 benzylation
of indoles with benzylic
alcohols is developed. The reaction proceeds with molecular iodine
as the catalyst under ligand-, metal-, and base-free conditions and tolerates wide functionalities. The
experimental observations account for the halogen-bond activation
mechanistic pathway for the molecular iodine catalysis.