op9b00265_si_001.pdf (795.2 kB)
Model-Based Scale-Up Predictions: From Micro- to Millireactors Using Inline Fourier Transform Infrared Spectroscopy
journal contribution
posted on 2019-08-19, 21:45 authored by Verena Fath, Stefanie Szmais, Philipp Lau, Norbert Kockmann, Thorsten RöderScale-up
predictions from a continuous flow micro- (lab) to milliscale
(pilot or production) are important but not trivial. To overcome the
necessity of time-consuming trials on the pilot or production scale,
this work presents a model-based approach that builds on prior lab
experiments. However, it also improves the understanding of the involved
chemical process. A complete process development for a highly exothermic
organometallic reaction is conducted. Kinetic studies on a lab scale,
using inline FT-IR measurements, constitute the basis for a systematic
scale-up approach. Subsequently, the scale-up from microreactors (inner
diameter of 0.5 mm) to milliscale pilot reactors (inner diameter of
2 mm) through increasing the channel diameter and flow rates is investigated.
Model-based scale-up predictions are presented, including heat and
mass balances.
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Spectroscopy Scale-up predictionsKinetic studiesmodel-based approachproduction scalemass balancesinline FT-IR measurementschemical process0.5 mmprocess developmentscale-up approachModel-based scale-up predictions2 mmlab experimentsInline Fourier Transformmilliscale pilot reactorslab scaleorganometallic reactionflow ratesModel-Based Scale-Up Predictionschannel diameter
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