Mn(OAc)₃‑Promoted Oxidative C_sp³–P Bond Formation through C_sp²–C_sp² and P–H Bond Cleavage: Access to β‑Ketophosphonates

The Mn­(OAc)₃-promoted oxidative phosphonylation of N,N-dimethylenaminones with H-phosphonates, involving a chemo- and regioselective C_sp²–C_sp² bond cleavage and C_sp³–P bond formation in one step, provided successfully functionalized β-ketophosphonates under mild reaction conditions. Oxidative C_sp³–H/P–H cross-coupling reactions via C_sp³–C­(CO) bond cleavage and mechanistic studies are conducted preliminarily, and a possible mechanism is proposed. This novel method proceeds in good to excellent yields, shows operational simplicity, broad substrate scope, and large-scale preparation.