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Mn-Catalyzed Electrochemical Radical Cascade Cyclization toward the Synthesis of Benzo[4,5]imidazo[2,1‑a]isoquinolin-6(5H)‑one Derivatives
journal contribution
posted on 2020-05-29, 15:04 authored by Yong Yuan, Yongfu Zheng, Bizhen Xu, Jiapeng Liao, Faxiang Bu, Shengchun Wang, Jian-Guo Hu, Aiwen LeiBenzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-one derivatives are
prevalent in many synthetic intermediates,
pharmaceuticals, and organic materials. Herein, we develop a Mn-catalyzed
electrochemical radical cascade cyclization reaction that uses electricity
as the primary energy input to promote the reaction, leading to a
series of benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-one derivatives under exogenous-oxidant-free conditions.
It is worth noting that this electrochemical method can not only realize
the synthesis of benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-one derivatives but also provides a new strategy for
generating alkyl radicals from alkylboronic acids.