jm500154f_si_001.pdf (1.62 MB)
Mixed Valence Copper(I,II) Binuclear Complexes with Unexpected Structure: Synthesis, Biological Properties and Anticancer Activity
journal contribution
posted on 2014-07-24, 00:00 authored by Alexander G. Majouga, Maria I. Zvereva, Maria
P. Rubtsova, Dmitry A. Skvortsov, Andrei
V. Mironov, Dulat M. Azhibek, Olga O. Krasnovskaya, Vasily M. Gerasimov, Anna V. Udina, Nikolay I. Vorozhtsov, Elena K. Beloglazkina, Leonid Agron, Larisa V. Mikhina, Alla V. Tretyakova, Nikolay V. Zyk, Nikolay S. Zefirov, Alexander V. Kabanov, Olga
A. DontsovaWe
have synthesized and characterized a panel of new binuclear
mixed valence Cu(I,II) complexes containing substituted 2-alkylthio-5-arylmethylene-4H-imidazolin-4-ones with unusual structure. These complexes
are shown to be cytotoxic for various cell lines. We have found that
these compounds did not intercalate DNA, inhibited number of polymerases
(telomerase predominantly), accumulated in the cell nucleus, and caused
DNA degradation. Preliminary studies revealed that lead compound inhibited
human breast adenocarcinoma growth in mice model.