ol5035047_si_001.pdf (5.69 MB)
Microwave-Promoted Tin-Free Iminyl Radical Cyclization with TEMPO Trapping: A Practical Synthesis of 2‑Acylpyrroles
journal contribution
posted on 2015-02-06, 00:00 authored by Yu Cai, Ankur Jalan, Aaron R. Kubosumi, Steven L. CastleMicrowave-promoted
iminyl radical cyclizations can be terminated
by trapping with TEMPO, affording functionalized adducts. The use
of alkynes as radical acceptors delivers a range of 2-acylpyrroles
in good yields. Toxic and hazardous reagents, which are frequently
employed in radical reactions, are not required. The O-phenyl oxime ether substrates are constructed in a single step from
readily available ketones.