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Microfluidic Pipette Tip for High-Purity and High-Throughput Blood Plasma Separation from Whole Blood
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posted on 2017-01-11, 18:53 authored by Byeongyeon Kim, Sein Oh, Dongwon You, Sungyoung ChoiBlood plasma separation from whole
blood is often limited by numerous
blood cells which can compromise separation processes and thus deteriorate
separation performance such as purity and throughput. To address this
challenge, we present a microfluidic pipet tip composed of slant array
ridges that enable autonomous blood cell focusing without significant
deviation as well as facilitating a high degree of parallelization
without compromising separation purity. With these advantages, we
achieved high-purity (99.88%) and high-throughput (904.3 μL
min–1) plasma separation from whole blood. In combination
with a smart pipet, we successfully demonstrated rapid, inexpensive,
and equipment-free blood plasma preparation for pretransfusion testing.
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