ja961373w_si_001.pdf (258.98 kB)
Michael Reaction of Stabilized Carbon Nucleophiles Catalyzed by [RuH2(PPh3)4]
journal contribution
posted on 1996-09-11, 00:00 authored by Enrique Gómez-Bengoa, Juan M. Cuerva, Cristina Mateo, Antonio M. EchavarrenThe Michael reaction of active methylene compounds
lacking cyano groups such as malonates, β-ketoesters,
1,3-diketones, 1,1-disulfones, nitrocompounds, Meldrum acid, and
anthrone with common acceptors proceeds in
acetonitrile solution in the presence of
[RuH2(PPh3)4] as the
catalyst. Cyano acetates, more acidic than malonates
in organic solvents, are also excellent substrates for this reaction.
In a number of cases, intramolecular aldol reactions
catalyzed by
[RuH2(PPh3)4] were also
observed as side reactions. Catalysis by other ruthenium and
rhodium complexes
has been examined. Selectivity studies performed with malonate and
disulfone donors indicate that the catalyst
selectively activates Michael donors that can coordinate with
ruthenium(II). Additionally, it has been shown
that
the reaction requires the presence of free phosphine. Therefore,
the Michael reaction of stabilized enolates appears
to be a ruthenium- and phosphine-catalyzed reaction. From a
practical point of view, the use of readily prepared
[RuH2(PPh3)4] as the
catalyst in acetonitrile provided the best solution for the Michael
reaction of active methylene
compounds.