ol800437s_si_002.pdf (883.14 kB)
Michael Addition of Ortho-Lithiated Aryloxiranes to α,β-Unsaturated Malonates: Synthesis of Tetrahydroindenofuranones
journal contribution
posted on 2008-05-15, 00:00 authored by Antonio Salomone, Vito Capriati, Saverio Florio, Renzo LuisiA short and efficient synthesis of tetrahydroindenofuranones based on the Michael addition of ortho-lithiated aryloxiranes to alkylidene malonates followed by the nucleophilic oxirane ring-opening and subsequent lactonization is described. The methodology has been applied to the synthesis of a structural analogue of epipodophyllotoxins.