jo8b00924_si_003.cif (1.18 MB)
Metal-Catalyzed Domino Synthesis of Benzophenanthridines and 6H‑Naphtho[2,3‑c]‑chromenes
dataset
posted on 2018-06-11, 00:00 authored by Baitan Chakraborty, Swapnadeep Jalal, Kartick Paul, Sandip Kundal, Umasish JanaA new and efficient synthesis of
tetracyclic phenanthridines and
benzo[c]chromenes has been described involving a
metal-mediated two-step domino strategy. The first step involved efficient
palladium-catalyzed domino carbopalladation/cross coupling, and the
second step involved iron-catalyzed domino isomerization/cyclodehydration.
The important features of this strategy include high yields, generality,
wide substrate scope, and broad functional group tolerance. A plausible
mechanism has been proposed to explain the formation of the product.