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Medium-Chain Fatty Acids Released from Polymeric Electrospun Patches Inhibit Candida albicans Growth and Reduce the Biofilm Viability
journal contribution
posted on 2020-06-01, 23:04 authored by Katharina
H. Clitherow, Tahani M. Binaljadm, Jens Hansen, Sebastian G. Spain, Paul V. Hatton, Craig MurdochOral candidiasis
is a very common oral condition among susceptible
individuals, with the main causative organism being the fungus Candida albicans. Current drug delivery systems to
the oral mucosa are often ineffective because of short drug/tissue
contact times as well as increased prevalence of drug-resistant Candida strains. We evaluated the potency of saturated
fatty acids as antifungal agents and investigated their delivery by
novel electrospun mucoadhesive oral patches using agar disk diffusion
and biofilm assays. Octanoic (C8) and nonanoic (C9) acids were the
most effective at inhibiting C. albicans growth on disk diffusion assays, both in solution or when released
from polycaprolactone (PCL) or polyvinylpyrrolidone/RS100 (PVP/RS100)
electrospun patches. In contrast, dodecanoic acid (C12) displayed
the most potent antifungal activity against pre-existing C. albicans biofilms in solution or when released
by PCL or PVP/RS100 patches. Both free and patch-released saturated
fatty acids displayed a significant toxicity to wild-type and azole-resistant
strains of C. albicans. These data
not only provide evidence that certain saturated fatty acids have
the potential to be used as antifungal agents but also demonstrate
that this therapy could be delivered directly to Candida-infected sites using electrospun mucoadhesive patches, demonstrating
a potential new therapeutic approach to treat oral thrush.
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agar disk diffusionMedium-Chain Fatty Acids Releasedantifungal agentssolutionPCLacidelectrospun mucoadhesive patchesfungus Candida albicansdrug-resistant Candida strainsbiofilmBiofilm Viability Oral candidiasisPVPdisk diffusion assaysCurrent drug delivery systemsnovel electrospun mucoadhesivePolymeric Electrospun Patches Inhibit Candida albicans Growth
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