Mechanical Control of Enantioselectivity of Amino Acid Recognition by Cholesterol-Armed Cyclen Monolayer at the Air-Water Interface

Monolayers of the cholesterol-armed cyclen Na<sup>+</sup> complex at the air−water interface display a remarkable, surface pressure dependent enantioselectivity of amino acid recognition. Upon compression of the monolayer, the binding constants of amino acids increase accompanying an inversion of chiral selectivity from the d- to l-form in the case of valine.