MeOTf-Mediated Annulation of Alkylnitriles and Arylalkynes Leading to Polysubstituted NH‑Pyrroles
2017-10-17T00:00:00Z (GMT)
by
A metal-free multicomponent domino
reaction for the highly regioselective
synthesis of tetrasubstituted NH-pyrroles from readily
available alkylnitriles, arylalkynes, and MeOTf has been developed.
A variety of NH-pyrroles were obtained in moderate
to good yields under mild conditions. In addition, the reactions using
diarylalkynes with electron-rich aryl groups were found to afford
isoquinolines.
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