jo7b01845_si_003.cif (214.27 kB)
MeOTf-Mediated Annulation of Alkylnitriles and Arylalkynes Leading to Polysubstituted NH‑Pyrroles
dataset
posted on 2017-10-17, 00:00 authored by Yu Liu, Xiangli Yi, Xuewei Luo, Chanjuan XiA metal-free multicomponent domino
reaction for the highly regioselective
synthesis of tetrasubstituted NH-pyrroles from readily
available alkylnitriles, arylalkynes, and MeOTf has been developed.
A variety of NH-pyrroles were obtained in moderate
to good yields under mild conditions. In addition, the reactions using
diarylalkynes with electron-rich aryl groups were found to afford
isoquinolines.