ol8b03652_si_002.pdf (8.72 MB)
Manganese-Catalyzed Asymmetric Oxidation of Methylene C–H of Spirocyclic Oxindoles and Dihydroquinolinones with Hydrogen Peroxide
journal contribution
posted on 2019-01-11, 00:00 authored by Bin Qiu, Daqian Xu, Qiangsheng Sun, Jin Lin, Wei SunA highly
efficient strategy for the enantioselective oxidation
of methylene C–H of spirocyclic oxindoles and dihydroquinolinones
has been established, in which an earth-abundant manganese catalyst
and hydrogen peroxide are used. Noteworthy, the manganese catalyst
can be applied to the asymmetric hydroxylation of spirocyclic 2,3-dihydroquinolin-4-ones
with 94–99% ee.
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eeSpirocyclic OxindolesHydrogen PeroxidemethylenedihydroquinolinstrategyDihydroquinolinoneenantioselective oxidation-4-onemanganese catalysthydrogen peroxideearth-abundant manganese catalystspirocyclic oxindolesdihydroquinolinoneManganese-Catalyzed Asymmetric OxidationNoteworthyhydroxylationMethylene
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