op0c00109_si_001.pdf (1.49 MB)
Management of the Heat of Reaction under Continuous Flow Conditions Using In-Line Monitoring Technologies
journal contribution
posted on 2020-05-14, 17:14 authored by Masahiro Hosoya, Shogo Nishijima, Noriyuki KuroseThis
work presents a guideline for managing process safety under
continuous flow conditions. In our previous work, we developed a Grignard
reaction for use under such conditions. This reaction was completed
in seconds and entailed a large amount of heat generation. To manage
the heat of reaction, we quantitatively analyzed the reaction rate
using ReactIR with a flow cell. The difference between quantitative
values from HPLC and ReactIR was less than 1%, and the reaction rate
was 94% in 0.4 s. Based on the reaction rate and the heat of reaction,
we simulated the distribution of the internal temperature along the
tube length and found the maximum difference from the measured internal
temperatures to be 5 °C. This accuracy was suitable for evaluating
and managing the heat of reaction. Our methodology can facilitate
the discussion of process safety under continuous flow conditions.