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Magnetic Nanoparticles Coated with (R)‑9-Acetoxystearic Acid for Biomedical Applications
journal contribution
posted on 2020-05-30, 00:13 authored by Gabriele Micheletti, Carla Boga, Dario Telese, Maria Cristina Cassani, Elisa Boanini, Patrizia Nitti, Barbara Ballarin, Alberto Ghirri, Gianni Barucca, Daniele RinaldiThe
well-known ability to selectively drive nanomagnetic materials
coated with anticancer drugs into tumor cells suggested the synthesis
and the characterization of magnetic nanoparticles (MNPs) functionalized
with (R)-9-acetoxystearic acid, the acetic ester
of (R)-9-hydroxystearic acid (9-HSA), an antiproliferative
agent active against different cancer cells. The acyl chloride of
(R)-9-acetoxystearic acid, synthesized in two steps
from 9-HSA, was reacted with (3-aminopropyl)triethoxysilane, chosen
as a linker between MNPs and the stearyl moiety. In the last step,
the novel amide was bound to magnetite NPs by reaction with silyl
groups. A detailed structural, chemical, and magnetic characterization
of the obtained material proved that it possesses properties in agreement
with the requirements for drug delivery, opening the possibility to
further insights focused on the 9-HSA biomedical applications.