ja7b09978_si_001.pdf (1.52 MB)
Magnesium Catalyzed Polymerization of End Functionalized Poly(propylene maleate) and Poly(propylene fumarate) for 3D Printing of Bioactive Scaffolds
journal contribution
posted on 2017-12-13, 00:00 authored by James
A. Wilson, Derek Luong, Alex P. Kleinfehn, Sahar Sallam, Chrys Wesdemiotis, Matthew L. BeckerThe ring-opening copolymerization
of maleic anhydride and propylene
oxide, using a functionalized primary alcohol initiator and magnesium
2,6-di-tert-butyl phenoxide as a
catalyst, was investigated in order to produce high end-group fidelity
poly(propylene maleate). Subsequent isomerization of the material
into 3D printable poly(propylene fumarate) was utilized to produce
thin films and scaffolds possessing groups that can be modified with
bioactive groups postpolymerization and postprinting. The surface
concentration of these modifiable groups was determined to be 30.0
± 3.3 pmol·cm–2, and copper-mediated azide–alkyne
cycloaddition was used to attach a small molecule dye and cell adhesive
GRGDS peptides to the surface as a model system. The films were then
studied for cytotoxicity and found to have high cell viability before
and after surface modification.
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Keywords
butyl phenoxidesurface modificationmaleic anhydridefumarateBioactive ScaffoldsSubsequent isomerization3 D Printingmolecule dyemodifiable groupsGRGDS peptidesmaleatesurface concentrationring-opening copolymerizationalcohol initiator3 Dcell viabilitypropylene oxideMagnesium Catalyzed Polymerizationfilmbioactive groups postpolymerizationmodel system
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