Machines vs Malaria: A Flow-Based Preparation of the
Drug Candidate OZ439

Lau, Shing-Hing; Galván, Alicia; Merchant, Rohan
R.; Battilocchio, Claudio; Souto, José A.; Berry, Malcolm
B.; Ley, Steven V.

doi:10.1021/acs.orglett.5b01307.s001

ol5b01307_si_001.pdf (846.26 kB)

Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439

journal contribution

posted on 2015-12-22, 22:41 authored by Shing-Hing Lau, Alicia Galván, Rohan R. Merchant, Claudio Battilocchio, José A. Souto, Malcolm B. Berry, Steven V. Ley

An efficient preparation of the antimalarial drug candidate OZ439, which was obtained by integrating a machine-assisted approach with batch processes, is reported. This approach allows a rapid and cost-effective production of the key intermediates that were readily elaborated into the target molecule.