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MRI Guided Magneto-chemotherapy with High-Magnetic-Moment Iron Oxide Nanoparticles for Cancer Theranostics
journal contribution
posted on 2020-03-12, 21:30 authored by Ashwini Salunkhe, Vishwajeet Khot, S. I. Patil, Syed A.M. Tofail, Joanna Bauer, Nanasaheb D. ThoratElevating
and monitoring the temperature of tumors using magnetic
nanoparticles (MNPs) still presents a challenge in magnetic hyperthermia
therapy. The efficient heating of tumor volume can be achieved by
preparing MNPs with high magnetization values. The next-generation
approach to magnetic resonance image (MRI)-guided magneto-chemotherapy
of cancer based on high-magnetic-moment iron oxide nanoparticles is
proposed. The proof of concept is validated by cellular MRI experiments
on breast cancer cells. To explore magneto-chemotherapy, we developed
high-magnetic-moment iron oxide (Fe3O4) nanoparticles
(NPs) using base diisopropylamine (DIPA), which plays a dual role
as reducing agent and surface stabilizer. Spherical NPs with ∼12
nm size and a high magnetization value of about 92 emu g–1 at room temperature are obtained by this unique method. A high specific
absorption rate value of ∼717 wg–1 was obtained
for Fe3O4 NPs in water at an alternating magnetic
field of 20 kAm–1 and frequency of 267 kHz, which
is attributed to the high magnetization value. The magneto-polymeric
micelle structure is formed by using Pluronic F127, and anticancer
drug doxorubicin is conjugated in the micelle by electrostatic interactions
for magneto-chemotherapy. Finally, the magnetic resonance imaging
(MRI)-guided magneto-chemotherapy was achieved on breast cancer (MCF7)
cells with an overall ∼96% killing of cancer cells attained
in 30 min of magneto-chmeotherapy.
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Cancer Theranostics Elevatingmagneto-polymeric micelle structureabsorption rate valueMNPDIPAtumorresonancebreast cancer cellshigh-magnetic-moment iron oxidehigh-magnetic-moment iron oxide nanoparticlesMRI Guided Magneto-chemotherapyFe 3 O 4High-Magnetic-Moment Iron Oxide Nanoparticlesmagnetization valueFe 3 O 4 NPsmagneto-chemotherapyMCFanticancer drug doxorubicin
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