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Low-Valent Niobium-Catalyzed Reduction of α,α,α-Trifluorotoluenes

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journal contribution
posted on 2007-04-12, 00:00 authored by Kohei Fuchibe, Yoshitaka Ohshima, Ken Mitomi, Takahiko Akiyama
In the presence of 5 mol % of niobium(V) chloride, α,α,α-trifluorotoluene derivatives were reduced with lithium aluminum hydride to give toluene derivatives in good yields. Stepwise, partial reduction of bis(trifluoromethyl)benzene derivative was also demonstrated.

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