Low Temperature Organocopper-Mediated Two-Component Cross Coupling/Cycloisomerization Approach Toward N-Fused Heterocycles
2008-06-05T00:00:00Z (GMT) by
Organocopper reagents smoothly react with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a “double duty” in this novel cascade transformation, which proceeds via an SN2′ substitution followed by a subsequent cycloisomerization step.
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