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Long-Term Efficacy of Biodegradable Metal–Polymer Composite Stents After the First and the Second Implantations into Porcine Coronary Arteries
journal contribution
posted on 2020-03-20, 14:59 authored by Xin Li, Wanqian Zhang, Wenjiao Lin, Hong Qiu, Yongli Qi, Xun Ma, Haiping Qi, Yao He, Hongjie Zhang, Jie Qian, Gui Zhang, Runlin Gao, Deyuan Zhang, Jiandong DingA biodegradable
coronary stent is expected to eliminate the adverse events of an otherwise
eternally implanting material after vessel remodeling. Both biocorrodible
metals and biodegradable polymers have been tried as the matrix of
the new-generation stent. Herein, we utilized a metal–polymer
composite material to combine the advantages of the high mechanical
strength of metals and the adjustable degradation rate of polymers
to prepare the biodegradable stent. After coating polylactide (PLA)
on the surface of iron, the degradation of iron was accelerated significantly
owing to the decrease of local pH resulting from the hydrolysis of
PLA, etc. We implanted the metal–polymer composite stent (MPS)
into the porcine artery and examined its degradation in vivo, with
the corresponding metal-based stent (MBS) as a control. Microcomputed
tomography (micro-CT), coronary angiography (CA), and optical coherence
tomography (OCT) were performed to observe the stents and vessels
during the animal experiments. The MPS exhibited faster degradation
than MBS, and the inflammatory response of MPS was acceptable 12 months
after implantation. Additionally, we implanted another MPS after 1-year
implantation of the first MPS to investigate the result of the MPS
in the second implantation. The feasibility of the biodegradable MPS
in second implantation in mammals was also confirmed.