np9b00322_si_001.pdf (7.57 MB)
Linear Peptides Containing d‑Leucine with Neuroprotective Activities from the Leech Whitmania pigra Whitman
journal contribution
posted on 2019-07-30, 20:29 authored by Zi-Yue Zhang, Nan Ma, Li-Jun Tao, Xue-Ying Gong, Wen-Cai Ye, Lei WangThree new linear peptides containing d-leucine, named
whitmantides A–C (1–3), were
isolated from the dried whole bodies of Whitmania pigra Whitman. Their structures with absolute configurations were elucidated
by Edman degradation, mass spectrometry, Marfey’s analysis,
and solid-phase synthesis. It is the first time that peptides containing d-amino acid in leeches were discovered. Compounds 1–3 displayed neuroprotective activities against
oxygen–glucose deprivation/reperfusion injury on Neuro-2a cells.
In addition, ex vivo serum stability tests showed that 1–3 were resistant to protease degradation.
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vivo serum stability testssolid-phase synthesismass spectrometryNeuroprotective ActivitiesNeuro -2a cellsd-leucineCompoundinjuryleechpeptidewhitmantideWhitmania pigra WhitmanLinear Peptides ContainingLeech Whitmania pigra Whitmand-amino acidMarfeyconfigurationanalysisneuroprotective activitiesprotease degradationEdman degradationdeprivation
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