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Limonoids from Aphanamixis polystachya and Their Antifeedant Activity
journal contribution
posted on 2014-03-28, 00:00 authored by Jie-Yun Cai, Duo-Zhi Chen, Shi-Hong Luo, Ning-Chuan Kong, Yu Zhang, Ying-Tong Di, Qiang Zhang, Juan Hua, Shu-Xi Jing, Shun-Lin Li, Sheng-Hong Li, Xiao-Jiang Hao, Hong-Ping HeEight new aphanamixoid-type aphanamixoids
(C–J, 1–8) and six new prieurianin-type
limonoids, aphanamixoids
K–P (9–14), along with 10
known terpenoids were isolated from Aphanamixis polystachya, and their structures were established by spectroscopic data analysis.
Among the new limonoids, 13 compounds exhibited antifeedant activity
against the generalist Helicoverpa armigera, a plant-feeding
insect, at various concentration levels. In particular, compounds 1, 4, and 5 showed potent activities
with EC50 values of 0.017, 0.008, and 0.012 μmol/cm2, respectively. On the basis of a preliminary structure–activity
relationship analysis, some potential active sites in the aphanamixoid-type
limonoid molecules are proposed.