ol9b02160_si_001.pdf (8.94 MB)
Ligand-Dependent-Controlled Copper-Catalyzed Regio- and Stereoselective Silaboration of Alkynes
journal contribution
posted on 2019-07-18, 11:37 authored by Meng Zhao, Cui-Cui Shan, Zi-Lu Wang, Chao Yang, Yao Fu, Yun-He XuA copper-catalyzed
highly regio- and stereoselective silaboration
of alkynes was developed. In this work, direct cis-difunctionalization
of alkynes was realized with silaboronate reagent and copper catalyst
in aprotic solvents. The regiodivergent silaborations were controlled
by tuning the copper catalysts and phosphine ligands used in reactions.
This protocol provides an efficient and practical method to synthesize
the multisubstituted functionalized alkenes with specific stereoselectivity.
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copper catalystsphosphine ligandsLigand-Dependent-Controlled Copper-Catalyzed Regiosilaboronate reagentmethodcis-difunctionalizationmultisubstituted functionalized alkenesAlkynestereoselectivitycopper-catalyzedStereoselective Silaborationaprotic solventsalkyneregiodivergent silaborationsstereoselective silaborationcopper catalyst
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