ol6b02430_si_002.cif (21.08 kB)
Lewis Acid and (Hypo)iodite Relay Catalysis Allows a Strategy for the Synthesis of Polysubstituted Azetidines and Tetrahydroquinolines
dataset
posted on 2016-10-10, 15:04 authored by Jing-Qiang Han, Huan-Huan Zhang, Peng-Fei Xu, Yong-Chun LuoA catalytic [3 + 1]-annulation reaction
between cyclopropane 1,1-diester
and aromatic amine is developed based on the relay catalysis strategy.
Lewis acid-catalyzed nucleophilic ring opening of cyclopropane 1,1-diester
with aromatic amine and (hypo)iodite-catalyzed C–N bond formation
are combined successfully in one reaction. Using this reaction, biologically
important azetidines and tetrahydroquinolines can be prepared directly.