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Large Scale Synthesis of Chiral (3Z,5Z)‑2,7-Dihydro‑1H‑azepine-Derived Hamari Ligand for General Asymmetric Synthesis of Tailor-Made Amino Acids
journal contribution
posted on 2019-01-18, 19:50 authored by Motohiro Takahashi, Hiroki Moriwaki, Toshio Miwa, Brittanie Hoang, Peng Wang, Vadim A. SoloshonokAn advanced process
for large scale (500 g) preparation of a (3Z,5Z)-2,7-dihydro-1H-azepine-derived
chiral tridentate ligand (Hamari ligand), widely used for asymmetric
synthesis of tailor-made α-amino acids via the corresponding
glycine Schiff base Ni(II) complex, is disclosed. The process includes
amidation, bis-alkylation, and precipitation/purification of the target
compound by TFA as a counterion.