Lactonecembranoids from Croton laevigatus

Zou, Guo-An; Ding, Gang; Su, Zhi-Heng; Yang, Jun-Shan; Zhang, Hone-Wu; Peng, Chao-Zhong; Aisa, Haiji Akber; Zou, Zhong-Mei

doi:10.1021/np100044t.s001

np100044t_si_001.pdf (1.47 MB)

Lactonecembranoids from Croton laevigatus

journal contribution

posted on 2010-04-23, 00:00 authored by Guo-An Zou, Gang Ding, Zhi-Heng Su, Jun-Shan Yang, Hone-Wu Zhang, Chao-Zhong Peng, Haiji Akber Aisa, Zhong-Mei Zou

Six new cembranoids, laevigatlactones A−F (1−6), and the known compound neocrotocembraneic acid (7) were isolated from leaves of Croton laevigatus. Their structures were elucidated on the basis of spectroscopic analysis, and that of 1 was confirmed by X-ray crystallography. Compound 2 exhibited modest cytotoxicity against HeLa cells, with an IC₅₀ value of 38.4 μM.