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Label-Free Fluorescent Mesoporous Bioglass for Drug Delivery, Optical Triple-Mode Imaging, and Photothermal/Photodynamic Synergistic Cancer Therapy
journal contribution
posted on 2020-03-11, 15:40 authored by Rajendra K. Singh, Amal George Kurian, Kapil D. Patel, Nandin Mandakhbayar, Na-Hyun Lee, Jonathan C. Knowles, Jung-Hwan Lee, Hae-Won KimNanomaterials combined
with phototherapy and multimodal imaging
are promising for cancer theranostics. Our aim is to develop fluorescent
mesoporous bioglass nanoparticles (fBGn) based on carbon dots (CD)
with delivery, triple-mode imaging, and photothermal (PTT) properties
for cancer theranostics. A direct and label-free approach was used
to prepare multicolor fluorescent fBGn with 3-aminopropyl triethoxysilane
as the surface-functionalizing agent. The calcination at 400 °C
provided fBGn with high fluorescence intensity originating from the
CD. In particular, a triple-mode emission [fluorescence imaging, two-photon
(TP), and Raman imaging] was observed which depended on CD nature
and surface properties such as surface oxidation edge state, amorphous
region, nitrogen passivation of surface state, and crystalline region.
The fBGn also exhibited phototherapeutic properties such as photodynamic
(PDT) and PTT effects. The antitumor effect of the combined PDT/PTT
therapy was significantly higher than that of individual (PDT or PTT)
therapy. The fBGn, due to the mesoporous structure, the anticancer
drug doxorubicin could be loaded and released in a pH-dependent way
to show chemotherapy effects on cancer cells. The in vivo imaging
and biocompatibility of fBGn were also demonstrated in a nude mouse
model. The fBGn, with the combined capacity of anticancer delivery,
triple-mode imaging, and PTT/PDT therapy, are considered to be potentially
useful for cancer theranostics.