Kottamides A−D:  Novel Bioactive
Imidazolone-Containing Alkaloids from the
New Zealand Ascidian Pycnoclavella kottae

Appleton, David R.; Page, Michael J.; Lambert, Gretchen; Berridge, Michael V.; Copp, Brent R.

doi:10.1021/jo0201427.s001

jo0201427_si_001.pdf (362.28 kB)

Kottamides A−D: Novel Bioactive Imidazolone-Containing Alkaloids from the New Zealand Ascidian Pycnoclavella kottae

journal contribution

posted on 2002-06-18, 00:00 authored by David R. Appleton, Michael J. Page, Gretchen Lambert, Michael V. Berridge, Brent R. Copp

Kottamides A−D (1−4), novel 2,2,5-trisubstituted imidazolone-containing alkaloids, were isolated from the New Zealand endemic ascidian Pycnoclavella kottae and structurally characterized using ¹⁵N natural abundance 2-D NMR in addition to standard spectroscopic methods. The kottamides exhibited anti-inflammatory and anti-metabolic activity as well as cytotoxicity toward tumor cell lines.