Isolation and Characterization of Atropisomers of Seven-Membered-Ring Benzolactams
journal contributionposted on 17.06.2011 by Hidetsugu Tabata, Naoya Wada, Yuko Takada, Tetsuta Oshitari, Hideyo Takahashi, Hideaki Natsugari
Any type of content formally published in an academic journal, usually following a peer-review process.
The atropisomeric properties of seven-membered-ring benzolactams (7a–c and 8a) [1,5-benzodiazepin-2-one (a), 1,5-benzothiazepin-4-one (b), and 1-benzazepin-2-one (c)] were examined. The atropisomers were isolated as the diastereomers with an (S)-phenethylamide moiety, which were characterized by X-ray crystallography, and the barriers to their interconversion were clarified.