jf401612t_si_001.pdf (1.36 MB)
Isolation, Identification, and Bioactivity of Monoterpenoids and Sesquiterpenoids from the Mycelia of Edible Mushroom Pleurotus cornucopiae
journal contribution
posted on 2016-02-19, 07:44 authored by Shaojuan Wang, Li Bao, Feng Zhao, Quanxin Wang, Shaojie Li, Jinwei Ren, Li Li, Huaan Wen, Liangdong Guo, Hongwei LiuEdible
mushroom is a profilic source of bioactive metabolites for the development
of drugs and nutraceuticals. In this work, four new monoterpenoids
(1–4) and one new sesquiterpenoid
(6) were isolated from the mycelia of edible mushroom Pleurotus cornucopiae fermented on rice. Their structures
were established by nuclear magnetic resonance, mass spectrometry,
and circular dichroism (CD) data analysis. Compound 1 possesses an unusual spiro[benzofuran-3,2′-oxiran] skeleton.
The absolute configuration of the 6,7-diol moieties in compounds 1, 2, and 6 was assigned using the in situ dimolybdenum CD method. Compounds 1–5, 7, and 8 showed
moderate inhibitory activity against nitric oxide production in lipopolysaccaride-activated
macrophages, with IC50 values in the range of 60–90
μM. Compounds 6 and 7 also exhibited
slight cytotoxicity against HeLa and HepG2 cells.