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Iron–Copper Bimetallic Nanocomposite Reinforced Dressing Materials for Infection Control and Healing of Diabetic Wound
journal contribution
posted on 2019-11-19, 17:05 authored by Madhumita Das, Upashi Goswami, Raghuram Kandimalla, Sanjeeb Kalita, Siddhartha Sankar Ghosh, Arun ChattopadhyayA multifunctional nanomaterial based wound healing matrix
was fabricated by modified co-precipitation and chemical reduction
method. The matrix was comprised of either a bimetallic Fe–Cu
nanocomposite powder or a wound bed made up of absorbent cotton swab
impregnated with bimetallic Fe–Cu nanocomposite. The detailed
analytical studies of both dressing materials (powder and cotton bed)
were carried out with transmission electron microscopy, X-ray diffraction,
field emission scanning electron microscopy, energy-dispersive X-ray,
and bright field microscopy. Both the nanocomposite powder and the
nanocomposite impregnated cotton swab exhibited antimicrobial activity
against Gram positive and Gram negative bacteria, including multidrug-resistant
bacteria (such as methicillin-resistant Staphylococcus aureus) as well as against fungus isolated from different human biological
samples (pus/tissue culture/urine). For real time applications, the
in vivo wound healing ability of both dressing materials was also
carried out in Wistar albino rats with infected diabetic wounds. These
biocompatible and biodegradable dressing materials with broad-spectrum
antimicrobial properties have exhibited more than 20 mm in diameter
zone of microbial growth inhibition against several types of microbes.
Remarkably, they have also been found to assist in healing of infected
diabetic wounds and show a prospect in the management of other infectious
wounds.