Iron-Mediated Annulation between Methylene Ketones and Diethanolamines: A Sustainable and Scalable Procedure toward N‑(2-Hydroxyethyl) Pyrroles

An iron-mediated direct annulation between methylene ketones and diethanolamines was developed for the efficient synthesis of N-(2-hydroxyethyl) pyrroles. This protocol shows high efficiency, operational simplicity, good functional group compatibility as well as broad substrates scope.