Iron-Mediated Annulation
between Methylene Ketones and Diethanolamines: A Sustainable and Scalable
Procedure toward N‑(2-Hydroxyethyl) Pyrroles

Hu, Weiming; Yu, Jin-Tao; Ye, Dengman; Zhou, Zhou; Sun, Song; Cheng, Jiang

doi:10.1021/acs.joc.6b01195.s002

jo6b01195_si_002.pdf (3.11 MB)

Iron-Mediated Annulation between Methylene Ketones and Diethanolamines: A Sustainable and Scalable Procedure toward N‑(2-Hydroxyethyl) Pyrroles

journal contribution

posted on 2016-09-07, 00:00 authored by Weiming Hu, Jin-Tao Yu, Dengman Ye, Zhou Zhou, Song Sun, Jiang Cheng

An iron-mediated direct annulation between methylene ketones and diethanolamines was developed for the efficient synthesis of N-(2-hydroxyethyl) pyrroles. This protocol shows high efficiency, operational simplicity, good functional group compatibility as well as broad substrates scope.